Preheat the grill to medium-high heat.

In a mixing bowl, combine the ground beef, salt, black pepper, garlic powder, and onion powder. Mix until just combined.

Divide the mixture into four equal parts and form into patties.

Place the patties on the preheated grill and cook for about 4-5 minutes on each side, until cooked through.

During the last minute of cooking, add a slice of cheese to each patty and close the grill lid to melt the cheese.

Remove the patties from the grill and let them rest for a few minutes.

To assemble, place the patty on a toasted bun and add lettuce, tomato, pickles, ketchup, and mustard to taste.